FRAME D5 Smart Bottle + N1, S1, Ω3DE Skincare Supplements


Water is the main component of the human body and it plays an important role in our lives. The human body is a machine designed to run on water and minerals. It is composed of approximately 72% water and water is vitally important for every bodily function. Without water, the body does not work; what is more consuming poor quality water can have a dramatic impact on your health. Therefore drinking healthy water is vitally important in our lives. The FRAME® – D5 device is a smart BPA-free bottle with a capacity of 450ml, specially designed to easily convert mineral water into hydrogen-rich water without spending any money.

How to operate
It only takes 5 minutes to produce a bottle of hydrogen-rich water. You must charge the bottle using the USB cable for at least one hour. The device can be powered by a power adapter, computer or mobile power pack, which is very convenient both for use at home or if you need to take it with you on the go. Once charged, you can fill up the bottle with water. We recommended using boiled tap water or still mineral water. Water with a high concentration of chloride cannot be directly electrolysed by the device. Press the “>” button (fig.1). A blue light will come on and you will see the water starting the electrolysis process. Wait for 5 minutes and then you can start drinking the water. If you are in a hurry, press the “>>” button (fig.2). The device will perform a rapid electrolysis process. Once the water is ready the device will stop the process but every time you move the bottle the process will restart. So simply add water and check the bottle is charged.

Applied Nutriceuticals & Skincare Supplements with hydrogen-rich water: Taking your daily FRAME® Applied Nutriceuticals (N,O) and Skincare Supplements (S) with hydrogen-rich water helps to improve their absorption and boost their benefits. Hydrogen-rich water also helps to remove impurities from the cells and the body, maximise anti-aging potential and improve hydration levels (up to 6 times better than tap water). We recommend drinking at least 1.5 l / 50 fl.oz of hydrogen-rich water daily during any skincare treatments.


S1 - Age Defender Antioxidant Skincare Supplement
30 tablets
Oxidative stress is a condition in which the body experiences an imbalance between the production and elimination of oxidising substances. These radical molecules play an important role in defending against bacteria, transmitting biochemical signals between cells and other physiological processes. However, when there are too many of them they become dangerous and lead to endothelial dysfunction. Oxidative stress is also at the basis of ageing processes, especially of the skin.

The composition of S1 makes it a product which is ideal for acting specifically on an epithelial tissue level. Evening Primrose oil is extracted from the seeds of a herbaceous plant local to the Mediterranean area and is an oil which is rich in fatty acids, particularly gamma-linolenic acid. This acid is responsible for its beneficial effect on the skin as it intervenes in prostaglandin synthesis by increasing the production of prostaglandin PGE1, which has anti-inflammatory and stabilising properties, increasing skin elasticity and inhibiting deterioration. Hyaluronic acid is added to this, providing the skin with moisturisation, elasticity and protection. Centella, with its triterpene components, including asiaticoside, enhances collagen synthesis and other factors involved in the vascular epithelial structure. This increases vessel strength and improves microcirculation. Green tea and vitamin E have antioxidant properties. The polyphenols contained in Camellia sinensis scavenge free radicals and inhibit cyclooxygenase and lipoxygenasae enzymes, at the same time stimulating the production of antioxidant enzymes such as superoxide dismutase. Alpha lipoic acid has been known for years as one of the most useful anti-ageing remedies as it preserves the correct functional and structural integrity of tissues and certain organs (the liver, for example), and optimises glucose metabolism in order to reduce the formation of advanced glycation end products, significant determinants of ageing. In summary, S1 is a powerful ally in the prevention of skin ageing.

Directions: Take one tablet in the evening after dinner with plenty of water. For better absorption and to increase the product’s effectiveness, we recommend taking the tablets with hydrogen-rich water obtained using the FRAME® D5 device.


N1 - Melatonin based applied nutriceutical
30 tablets
Melatonin (N-acetyl-5-methoxytryptamine) is a derivative of the amino acid Tryptophan and widely distributed in food sources, such as milk, almonds, bananas, beets, cucumbers, mustard, and tomatoes. In humans, melatonin is primarily synthesized by the pineal gland. Melatonin has been shown to support circadian rhythm, hormone balance, reproductive health, cognition, mood, blood sugar regulation, and bone metabolism, while lowering blood pressure and improving overall antioxidant status with powerful role in fighting free-radical- related diseases. Melatonin is known for helping some people achieve a better night’s sleep, which is how it earned its nickname as “the sleep hormone,” and scientific evidence now suggests that it plays a crucial role in a variety of metabolic functions, including neuroprotection, anti-inflammatory defense, and immune system support. Melatonin has been found to possess 200% more antioxidant power than vitamin E and to be superior to Glutathione as well as vitamins C in reducing oxidative damage. As such a potent antioxidant, melatonin plays a powerful role in fighting free-radical-related diseases. The N1 is produced in Italy by our laboratories using the highest quality ingredients and technology.

Directions: Take one tablet in the evening, half an hour before going to bed. For better absorption and to increase the product’s effectiveness, we recommend taking the tablets with hydrogen-rich water obtained using the FRAME® D5 device.


Ω3DE – Pure Mediterranean Fatty Acids + Vitamins
30 tablets
Fish oil is oil derived from the tissues of oily fish. Fish oils contain the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), precursors of certain eicosanoids that are known to reduce inflammation in the body. The most widely available dietary source of EPA and DHA is cold-water oily fish, such as salmon, herring, mackerel, anchovies, and sardines.
Oils from these fish have a profile of around seven times as much omega-3 oils as omega-6 oils. DHA is a structural component of the skin. It is responsible for the health of cell membranes, which make up a large part of skin. A healthy cell membrane results in soft, moist, supple and wrinkle-free skin. EPA also benefits the skin in several ways, including: managing oil production in skin; managing skin hydration; preventing hyperkeratinisation of hair follicles (the little red bumps often seen on upper arms) and preventing premature ageing of the skin. Omega-3s can also protect your skin from sun damage. EPA helps block the release of substances that eat away at the collagen in your skin after sun exposure. One of the main roles that vitamin D plays in the body is that of keeping our brain and nervous system healthy. It is important for the reabsorption of calcium by the kidneys and the absorption of phosphorous by the intestines, two basic factors for tooth and bone health. It helps to maintain normal functioning of muscles and the immune system and to regulate insulin levels in the management of type-2 diabetes.
According to recent studies, vitamin D has anti-proliferative properties towards diseased cells and it plays a fundamental role in cell growth and intercellular communication.
Vitamin E has properties which are mainly linked to its powerful antioxidant effect. Its action against free radicals triggers physiological reactions which render cellular membranes stronger and protect red blood cells, which are among the cells in our body most exposed to oxidative stress. As it is an antioxidant, it is capable of reducing oxidative stress in numerous physiological processes and of thus protecting the body from damage caused by various harmful factors such as UV rays, cigarette smoke and cell damage caused by ageing. It protects the cardiocirculatory system: in fact a connection between low levels of vitamin E in the blood and coronary diseases, arteriosclerosis and high cholesterol has been found. It also appears to be useful in preventing various kinds of thrombosis and blood coagulation problems and in preventing and treating various chronic pathologies linked to oxidative stress. It also protects the immune system, which comprises mainly antibodies and intestinal bacterial floral. Lastly, vitamin E supplements prevent or slow down the progress of eye diseases like cataracts or macular degeneration.

Directions: Take two tablets a day (one in the morning after breakfast and one in the evening after dinner) with plenty of water. For better absorption and to increase the product’s effectiveness, we recommend taking the tablets with hydrogen-rich water obtained using the FRAME® D5 device.



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