FRAME D5 Smart Bottle + N2, S2, Ω3DE Skincare Supplements


Water is the main component of the human body and it plays an important role in our lives. The human body is a machine designed to run on water and minerals. It is composed of approximately 72% water and water is vitally important for every bodily function. Without water, the body does not work; what is more consuming poor quality water can have a dramatic impact on your health. Therefore drinking healthy water is vitally important in our lives. The FRAME® – D5 device is a smart BPA-free bottle with a capacity of 450ml, specially designed to easily convert mineral water into hydrogen-rich water without spending any money.

How to operate
It only takes 5 minutes to produce a bottle of hydrogen-rich water. You must charge the bottle using the USB cable for at least one hour. The device can be powered by a power adapter, computer or mobile power pack, which is very convenient both for use at home or if you need to take it with you on the go. Once charged, you can fill up the bottle with water. We recommended using boiled tap water or still mineral water. Water with a high concentration of chloride cannot be directly electrolysed by the device. Press the “>” button (fig.1). A blue light will come on and you will see the water starting the electrolysis process. Wait for 5 minutes and then you can start drinking the water. If you are in a hurry, press the “>>” button (fig.2). The device will perform a rapid electrolysis process. Once the water is ready the device will stop the process but every time you move the bottle the process will restart. So simply add water and check the bottle is charged.

Applied Nutriceuticals & Skincare Supplements with hydrogen-rich water: Taking your daily FRAME® Applied Nutriceuticals (N,O) and Skincare Supplements (S) with hydrogen-rich water helps to improve their absorption and boost their benefits. Hydrogen-rich water also helps to remove impurities from the cells and the body, maximise anti-aging potential and improve hydration levels (up to 6 times better than tap water). We recommend drinking at least 1.5 l / 50 fl.oz of hydrogen-rich water daily during any skincare treatments.


S2 – Intensive Metabolic Repair Supplement
30 tablets
Useful for promoting all-round wellbeing, its active ingredients help counter the main phenomena usually associated with ageing, reintegrating nutritional components and the substances the body needs, and rebalancing normal biological processes.
- HYDROLYSED COLLAGEN: Collagen is a protein which makes up the skin’s structure, providing tone and elasticity and countering the appearance of wrinkles. At the same time collagen is the main fibrous component of bone, tendons, teeth and cartilage, constituting more than 30% of protein in the human body (a percentage that rises to 70% for skin). The need to take oral supplements of collagen arises from its diminished synthesis during ageing and also from the particular amino acid composition of this protein. Collagen supplements constantly provide the body with all the amino acids needed for its synthesis.
- RESVERATROL: Resveratrol is the most famous and researched of the polyphenols extracted from grape skins, due to its well-known antioxidant and anti-ageing properties. It acts as a precious ally to the skin, combating loss of elasticity and the appearance of wrinkles and dark spots.
- ALPHA LIPOIC ACID: It can be considered a fully-fledged member of the antioxidant family both for its effectiveness in countering oxidative stress and its ability to regenerate other antioxidants like vitamin E, vitamin C and glutathione. Strengthening the skin’s antioxidant defences is essential for countering premature skin ageing phenomena. In fact, there is a close relationship between skin ageing and oxidative damage caused by free radicals, as polyunsaturated fatty acids, which are the principle constituent of the horny layer of the skin, are the main target of reactive oxygen species (ROS) and free radicals.
- HYALURONIC ACID: It is well-known for its ability to bind to a high number of water molecules, ensuring skin remains moisturised. From close examination of scientific literature it can be concluded that oral consumption contributes to increasing the amount of hyaluronic acid in the body. This leads to higher levels of moisturisation, resulting in smoother, more moisturised skin. By firming tissue, hyaluronic acid thus results in a temporary filling in and smoothing over of fine lines, an effect that can be added to that ensuing from the topical application of hyaluronic acid.
- VITAMIN E: It is the most important lipophilic antioxidant found in the human body, due to its cell membrane stabilising action. As far as anti-wrinkle and anti-ageing effects are concerned, the antioxidant properties of vitamin E on the skin are essential for countering premature skin ageing induced by oxidative stress.
- BROCCOX ®: An important property of the Brassica family is the capacity to “switch on” genes that produce cellular enzymes required for optimum cell function. The most significant of these are the genes for the three most important phase-2 detoxification enzymes: quinone reductase (QR), glutathione S-transferase (GST) and uridine diphospho–glucuronosyltransferase (UGT). These enzymes convert toxins into water-soluble substances that are readily excreted. Induction of phase-2 proteins also encourages the removal of oxidants or impedes their formation. The sulphoraphane contained stimulates the immune system and inhibits proinflammatory cytokines.

Directions: Take one tablet in the morning after breakfast with plenty of water. For better absorption and to increase the product’s effectiveness, we recommend taking the tablets with hydrogen-rich water obtained using the FRAME® D5 device.


N2 – Regenerative Mix Applied Nutriceutical
30 tablets
Your body is a highly technical and sophisticated machine. It operates as a single entity but it is made up of a number of systems that are dependent on each other. Everything we eat and drink directly affects our cells, which need specific vitamins and minerals depending on the role they have to perform. If you don’t eat a variety of nutritious foods, some supplements help you get adequate amounts of essential nutrients. However, supplements should not be considered as substitutes for the variety of foods that are important to a healthy diet.

N2 is a nutraceutical concentrate of:
– CAFFTOP®: An exclusive dry extract that comes from the simultaneous and balanced extraction of three carefully selected raw materials: Guarana seed (Paullinia Cupana Kunth), containing caffeine, which helps the body to burn fat stored primarily in subcutaneous adipose tissue and can therefore be useful in the slimming process. This plant is used in the treatment of mental fatigue, as an adjuvant in slimming regimes and to facilitate renal excretion of water.
– MATE LEAF EXTRACT (Ilex Paraguariensis A. St. Hill): Yerba Mate has been used as a beverage since the time of the ancient Indians of Brazil and Paraguay. It is used as a tonic, diuretic and as a stimulant to reduce fatigue, suppress the appetite and aid gastric function. It’s also used as a depurative (to promote cleansing and excretion of waste), to stimulate the nervous and muscular systems and for digestive problems, weight loss and physical and mental fatigue.
– COLA NUT EXTRACT (Cola Acuminata Schott et Endl.): Contains xanthines, the same type of alkaloids found in tea and coffee. Common among these xanthine derivatives are caffeine, theophylline and theobromine. These xanthines are known to stimulate gastric acid secretion and improve the utilisation of fatty acids as a fuel source.
– CAPSIRED® (Capsicum fruit-coated granulated extract): Beneficial influences of capsaicin on the gastrointestinal system include a digestive stimulant action and modulation of the intestinal ultra structure so as to enhance permeability to micronutrients. The antioxidant and anti-inflammatory properties of capsaicin have been established in a number of studies. The chemopreventive potential of capsaicin has been evidenced in cell line studies. The health beneficial hypocholesterolemic influence of capsaicin besides being cardio protective has other implications: the prevention of cholesterol gallstones and the protection of the structural integrity of erythrocytes under conditions of hypercholesterolemia.

Directions: Take one tablet in the morning after breakfast with plenty of water. For better absorption and to increase the product’s effectiveness, we recommend taking the tablets with hydrogen-rich water obtained using the FRAME® D5 device.


Ω3DE – Pure Mediterranean Fatty Acids + Vitamins
30 tablets
Fish oil is oil derived from the tissues of oily fish. Fish oils contain the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), precursors of certain eicosanoids that are known to reduce inflammation in the body. The most widely available dietary source of EPA and DHA is cold-water oily fish, such as salmon, herring, mackerel, anchovies, and sardines.
Oils from these fish have a profile of around seven times as much omega-3 oils as omega-6 oils. DHA is a structural component of the skin. It is responsible for the health of cell membranes, which make up a large part of skin. A healthy cell membrane results in soft, moist, supple and wrinkle-free skin. EPA also benefits the skin in several ways, including: managing oil production in skin; managing skin hydration; preventing hyperkeratinisation of hair follicles (the little red bumps often seen on upper arms) and preventing premature ageing of the skin. Omega-3s can also protect your skin from sun damage. EPA helps block the release of substances that eat away at the collagen in your skin after sun exposure. One of the main roles that vitamin D plays in the body is that of keeping our brain and nervous system healthy. It is important for the reabsorption of calcium by the kidneys and the absorption of phosphorous by the intestines, two basic factors for tooth and bone health. It helps to maintain normal functioning of muscles and the immune system and to regulate insulin levels in the management of type-2 diabetes.
According to recent studies, vitamin D has anti-proliferative properties towards diseased cells and it plays a fundamental role in cell growth and intercellular communication.
Vitamin E has properties which are mainly linked to its powerful antioxidant effect. Its action against free radicals triggers physiological reactions which render cellular membranes stronger and protect red blood cells, which are among the cells in our body most exposed to oxidative stress. As it is an antioxidant, it is capable of reducing oxidative stress in numerous physiological processes and of thus protecting the body from damage caused by various harmful factors such as UV rays, cigarette smoke and cell damage caused by ageing. It protects the cardiocirculatory system: in fact a connection between low levels of vitamin E in the blood and coronary diseases, arteriosclerosis and high cholesterol has been found. It also appears to be useful in preventing various kinds of thrombosis and blood coagulation problems and in preventing and treating various chronic pathologies linked to oxidative stress. It also protects the immune system, which comprises mainly antibodies and intestinal bacterial floral. Lastly, vitamin E supplements prevent or slow down the progress of eye diseases like cataracts or macular degeneration.

Directions: Take two tablets a day (one in the morning after breakfast and one in the evening after dinner) with plenty of water. For better absorption and to increase the product’s effectiveness, we recommend taking the tablets with hydrogen-rich water obtained using the FRAME® D5 device.



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